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Storage is the Key to Survival

  • The key to energy storage, which is absolutely necessary for survival, is insulin
  • In more advanced animals, including humans, insulin is made in a “safer location” – the pancreas, and not the intestine
  • However, a messenger connecting the intestine to the pancreas is necessary
  • These messengers have been named “incretin hormones” and are likewise vital for survival
  • A landmark HUMAN study was published in 1964 in Lancet, one of the world’s top medical journals
    • It showed that blood insulin levels were about 3 times greater after humans consumed glucose compared to when it was given intravenously (IV), while blood glucose levels were similar
    • Thus, something in the intestine was responsible for 2/3 of the effect; the yet to be identified incretin hormones
    • The principle incretin hormone proved to be gastric inhibitory polypeptide (GIP)

 

McIntyre N et al. Lancet 1964; 2:20-21
Saltiel AR and Kahn CR. Nature 2001; 414:799-806

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